In the generally annoying vein of journalists writing about science comes this. All of the items Mr. Horgan, apparent journalism school graduate, cites as regress are signs of progress. I think this points to a huge gulf between science and journalism. In journalism, realizing your proposed narrative is wrong means that you're back to where you started; in science, realizing your proposed narrative is wrong means you've made a giant leap forward in understanding.
Just think: how often do we see articles about, say, city government where the author has as its main point that there is no narrative?
The key point is that frequently in science knowing more means we realize we know less.
I actually see one of Horgan's observations:
What I found fascinating was the issue's overall tone of caution rather than the traditional boosterish enthusiasm.
as progress in itself. "Boosterish enthusiasm" is, in my view, bad for scientific progress.
On to the examples ...
The end of infectious disease
We used to think this was a) possible, and b) if possible, economically feasible. We've come to realize that evolution can be more powerful than our technology.
Space colonization
This will probably still happen soon on the scale of the lifetime of the solar system with our currently main sequence star, so don't fret, Trekkies. But if you can tell me what the point of the ISS is beyond a giant subsidy to Boeing to maintain some of our space infrastructure, I will give you a thousand dollars. I have never seen a peer-reviewed paper come out of the ISS; nearly all of the science is done by unmanned probes.
But the real problem I have is that colonization is not science. It being nearly Thanksgiving, a seasonal example: the Mayflower was not a scientific voyage.
Supersonic transport
The science behind supersonic flight happened before 1947. The fact that it is not economical to send hundreds of people at a time to business meetings and/or tropical islands faster than the speed of sound, but is economical to send one person and thousands of pounds of bombs is not a scientific fact.
Commercial fusion power
This turned out to be much harder than we thought; I myself was discouraged by my advisors from pursuing this field back in the 1990s. However missing a 20 year guess at commercial viability 30 years ago does not mean the field is going backward. It is still moving very, very slowly forward. Additionally, arguments against fusion's commercial viability are themselves due to progress in the field. We understand the problem better, and therefore understand that it is not likely to be economical anytime soon.
The origin of life